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I7000000 Sigma-Aldrich

Itraconazole

European Pharmacopoeia (EP) Reference Standard

Synonym: Oriconazole, R51211, Sporanox

  • CAS Number 84625-61-6

  • Empirical Formula (Hill Notation) C35H38Cl2N8O4

  • Molecular Weight 705.63

  •  MDL number MFCD00870168

  •  PubChem Substance ID 329815313

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards I - K, Pharmacopeia & Metrological Institutes Standards More...
InChI Key   VHVPQPYKVGDNFY-UHFFFAOYSA-N
form   neat
Featured Industry   Pharmaceutical (small molecule)
format   neat
storage temp.   2-8°C

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Itraconazole inhibits cytochrome P-450-dependent enzymes which results in the inhibition of ergosterol synthesis. It does so by interacting with 14-α demethylase, which is a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Ergosterol is a crucial compenent of fungal cell membranes. Therefore, it′s inhibition results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

Packaging

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference subtance catalogue.

Caution

Please find SDS provided by EDQM here..

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles

Articles

LC/MS Analysis of Antifungals on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antifungals on Ascentis® Express Biphenyl
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UHPLC Analysis of Antifungals on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Antifungals on Ascentis® Express C18
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

UHPLC Analysis of Antifungals on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Antifungals on Titan™ C18
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

Peer-Reviewed Papers
15

References

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PHR1834 Itraconazole, Pharmaceutical Secondary Standard; Certified Reference Material

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