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IRMM468

Thyroxine (T4)

IRMM® certified Reference Material

Synonym: 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, L-Thyroxine, T4

  • CAS Number 51-48-9

  • Linear Formula HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H

  • Molecular Weight 776.87

  •  Beilstein/REAXYS Number 2228515

  •  MDL number MFCD00002595

  •  PubChem Substance ID 329815696

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, Reference Materials from the European Commission′s Joint Research Centre (formerly IRMM)
grade   IRMM® certified Reference Material
form   neat
mfr. no.   JRC
mp   223 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
storage temp.   −70°C
SMILES string   N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
InChI   1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
InChI key   XUIIKFGFIJCVMT-LBPRGKRZSA-N
Gene Information   human ... THRA(7067), THRB(7068)

Description

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Analysis Note

For more information please see:
IRMM468

Legal Information

IRMM is a registered trademark of European Commission

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Thyroxine Enantiomers on Astec® CHIROBIOTIC® TAG

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Thyroxine Enantiomers on Astec® CHIROBIOTIC® TAG
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Hormones, Mass spectrometry

LC/MS Analysis of Thyroid Hormones on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Thyroid Hormones on Ascentis® Express F5
Keywords: Chromatography, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Metabolites

LC/MS Analysis of thyroid hormones on Titan™ PFP

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of thyroid hormones on Titan™ PFP
Keywords: High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Metabolites

LC/MS with Online Solid Phase Extraction (SPE-LC/MS) of Thyroid Hormones in Plasma on Ascentis® Express Phenyl-Hexyl using RP-Amide Traps

From our library of Articles, Sigma-Aldrich presents LC/MS with Online Solid Phase Extraction (SPE-LC/MS) of Thyroid Hormones in Plasma on Ascentis® Express Phenyl-Hexyl using RP-Amide Traps
Keywords: Chromatography, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Sample preparations, Separation, Solid phase extractions, Solvents

Peer-Reviewed Papers
15

References

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