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M1900000 Sigma-Aldrich

Miconazole nitrate

European Pharmacopoeia (EP) Reference Standard

Synonym: (±)-Miconazole nitrate salt, 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

  • CAS Number 22832-87-7

  • Empirical Formula (Hill Notation) C18H14Cl4N2O · HNO3

  • Molecular Weight 479.14

  •  MDL number MFCD00058161

  •  PubChem Substance ID 329817922

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards L - M, Pharmacopeia & Metrological Institutes Standards More...
InChI Key   MCCACAIVAXEFAL-UHFFFAOYSA-N
form   neat
Featured Industry   Pharmaceutical (small molecule)
format   neat

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

Packaging

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference subtance catalogue.

Caution

Please find SDS provided by EDQM here..

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles

Articles

HPLC Analysis of Miconazole Enantiomers on Astec® CYCLOBOND® I 2000 RSP

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Miconazole Enantiomers on Astec® CYCLOBOND® I 2000 RSP
Keywords: Antibiotics, Antimicrobials, Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

Related Products

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Description

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PHR1163 (±)-Miconazole nitrate salt, Pharmaceutical Secondary Standard; Certified Reference Material
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