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M2772 Sigma-Aldrich

Menthol

99%

Synonym: 2-Isopropyl-5-methylcyclohexanol, Hexahydrothymol

  • CAS Number 89-78-1

  • Empirical Formula (Hill Notation) C10H20O

  • Molecular Weight 156.27

  •  Beilstein/REAXYS Number 3194263

  •  EC Number 201-939-0

  •  MDL number MFCD00001484

  •  PubChem Substance ID 24896764

  •  NACRES NA.25

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Properties

Related Categories Cell Biology, Nutrition Research, Phytochemicals by Chemical Classification, Terpenes and Terpenoids (Isoprenoids)
Quality Level   200
vapor pressure   0.8 mmHg ( 20 °C)
assay   99%
bp   216 °C (lit.)
mp   34-36 °C (lit.)
density   0.89 g/mL at 25 °C (lit.)
SMILES string   CC(C)C1CCC(C)CC1O
InChI   1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3
InChI key   NOOLISFMXDJSKH-UHFFFAOYSA-N
Gene Information   human ... TRPA1(8989), TRPM8(79054)

Description

General description

Menthol (C10H20O) is a terpenoid compound. It is extracted from the plants belonging to Mentha genus in the Lamiaceae family.

Menthol is a cyclic monoterpene alcohol, which is extracted from essential oils of Mentha canadensis and Mentha x piperita. It possesses antimicrobial, anticancer and anti-inflammatory properties. Menthol acts as a transient receptor potential cation channel (TRPM8) agonist. It also exhibits analgesic, antipruritic, anesthetic and cooling effects.

Application

Menthol has been used:
• to test its antifungal susceptibility
• to determine its efficacy as an anesthetic in fish
• to activate transient receptor potential cation channel (TRPM8)
• as an odorant for measuring sniffing dynamics

Packaging

5, 100, 500 g in poly bottle

Biochem/physiol Actions

Menthol exhibits antifungal action on the membrane permeability and the cell wall consistency, this might leads to cell death or inhibition of the C. albicans filamentation. Therefore, it can be used as a potential therapeutic agent for candidiasis. In addition to antifungal activity, menthol also exhibits anesthetic, antispasmodic, anti-ulcer and antiviral properties. It is considered as a safe compound for animal life. Therefore, Menthol is widely used in pharmaceuticals, cosmetics and food industries.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
OT0350000
Flash Point(F) 
204.8 °F
Flash Point(C) 
96 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Essential Oil on SLB®-5ms

From our library of Articles, Sigma-Aldrich presents Essential Oil on SLB®-5ms
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Fragrance Compounds in Shampoo Base on a 100% Methyl Column after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Fragrance Compounds in Shampoo Base on a 100% Methyl Column after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Cosmetics, Gas chromatography, Mass selective detector, Purification, Solid phase microextractions

GC Analysis of Peppermint Essential Oil on SLB®-IL59

From our library of Articles, Sigma-Aldrich presents GC Analysis of Peppermint Essential Oil on SLB®-IL59
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Spearmint Essential Oil on SLB®-IL59

From our library of Articles, Sigma-Aldrich presents GC Analysis of Spearmint Essential Oil on SLB®-IL59
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

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Peer-Reviewed Papers
15

References

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