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N1636 Sigma-Aldrich

β-Nicotinamide adenine dinucleotide hydrate

purified by column chromatography, ≥99%

Synonym: β-DPN, β-NAD, Coenzyme 1, Cozymase, DPN, Diphosphopyridine nucleotide, NAD, Nadide

  • CAS Number 53-84-9

  • Empirical Formula (Hill Notation) C21H27N7O14P2 · xH2O

  • Molecular Weight 663.43 (anhydrous basis)

  •  EC Number 200-184-4

  •  MDL number MFCD00036253

  •  eCl@ss 39200202

  •  PubChem Substance ID 24897510

  •  NACRES NA.55

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Properties

Related Categories Biochemicals and Reagents, Bulk vials, Cell Biology, Cofactors, Cofactors and Substrates,
Quality Level   200
assay   ≥99%
form   crystalline powder
color   white
storage temp.   −20°C
SMILES string   NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
InChI   1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChI key   BAWFJGJZGIEFAR-NNYOXOHSSA-N
Gene Information   human ... ESR1(2099), ESR2(2100)

Description

General description

β-Nicotinamide adenine dinucleotide (NAD) is an electron carrier and a cofactor. It is ubiquitously found in the living system. NAD+ contains an adenylic acid and a nicotinamide-5′-ribonucleotide group linked together by a pyrophosphate moiety. In NAD+ complexes, the enzyme-cofactor interactions are highly conserved.

Application

β-Nicotinamide adenine dinucleotide hydrate has been used:
• to measure adenosine triphosphate (ATP) synthesis rates (kinetics measurements)
• in the reaction buffer for pyruvate kinase (PK) activity assay
• as a component of master mix for a high throughput screening

Packaging

1 g in poly bottle

25, 100, 250 mg in poly bottle

Biochem/physiol Actions

β-Nicotinamide adenine dinucleotide (NAD) cycles between the oxidized (NAD+) and reduced (NADH) forms to maintain a redox balance necessary for continued cell growth. It significantly participates in enzyme-catalyzed oxido-reduction processes and many genetic processes. It is also involved in microbial catabolism.

Electron acceptor

Packaging

Packaged by solid weight.

Other Notes

Crystalline NAD contains less than 0.1% (w/w) residual organic solvent, is less hygroscopic and electrostatic, and is more stable at ambient temperatures than amorphous NAD.

This is the common form of NAD.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UU3450000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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