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N5410 Sigma-Aldrich

Nicotinic acid

meets USP testing specifications

Synonym: 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3

  • CAS Number 59-67-6

  • Empirical Formula (Hill Notation) C6H5NO2

  • Molecular Weight 123.11

  •  Beilstein/REAXYS Number 109591

  •  EC Number 200-441-0

  •  MDL number MFCD00006391

  •  PubChem Substance ID 24897734

  •  NACRES NA.21

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Properties

Related Categories Analytical/Chromatography, Biochemicals and Reagents, Cell Culture, Core Bioreagents, Pharmacopoeia,
Quality Level   200
biological source   synthetic (organic)
assay   99.0-101.0% dry basis
form   powder
color   white
mp   236-239 °C (lit.)
suitability   meets USP testing specifications
Featured Industry   Pharmaceutical (small molecule)
SMILES string   OC(=O)c1cccnc1
InChI   1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChI key   PVNIIMVLHYAWGP-UHFFFAOYSA-N
Gene Information   human ... CYP1A2(1544)
rat ... Chrnb2(54239)

Description

General description

Nicotinic acid, also referred to as niacin or as vitamin B3, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.

Application

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.

Biochem/physiol Actions

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
QT0525000
Flash Point(F) 
379.4 °F
Flash Point(C) 
193 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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