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P3640000 Sigma-Aldrich

Propyl gallate

European Pharmacopoeia (EP) Reference Standard

Synonym: 3,4,5-Trihydroxybenzoic acid propyl ester

  • CAS Number 121-79-9

  • Linear Formula 3,4,5-(HO)3C6H2CO2CH2CH2CH3

  • Molecular Weight 212.20

  •  Beilstein/REAXYS Number 1877976

  •  MDL number MFCD00002196

  •  PubChem Substance ID 329820183

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards P - R, Pharmacopeia & Metrological Institutes Standards More...
InChI Key   ZTHYODDOHIVTJV-UHFFFAOYSA-N
form   neat
mp   146-149 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.

Biochem/physiol Actions

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

Packaging

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference subtance catalogue.

Caution

Please find SDS provided by EDQM here..

Reconstitution

Prepare a 0.1M solution in glycerol:PBS (9:1)

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles

Articles

GC Analysis of Antioxidants on SAC™-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Antioxidants on SAC™-5
Keywords: Chromatography, Cosmetics, Flame ionization detector, Gas chromatography, Purification

HPLC Analysis of Antioxidants on SUPELCOSIL™ LC-18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antioxidants on SUPELCOSIL™ LC-18
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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PHR1118 Propyl gallate, Pharmaceutical Secondary Standard; Certified Reference Material
08168 Timestrip Plus 8 °C

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