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PHR1000 Supelco

Dextrose

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: D-(+)-Glucose, Dextrose

  • CAS Number 50-99-7

  • Empirical Formula (Hill Notation) C6H12O6

  • Molecular Weight 180.16

  •  Beilstein/REAXYS Number 1724615

  •  EC Number 200-075-1

  •  MDL number MFCD00063774

  •  PubChem Substance ID 329823031

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, C-D, Carbohydrate Standards, Chinese Food Contact Materials Regulation GB 9685 2016,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
assay   99.9%
analyte chemical class(es)   oligosaccharides
application(s)   HPLC: suitable
  detection: suitable
  gas chromatography (GC): suitable
mp   150-152 °C (lit.)
Featured Industry   Food and Beverages
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur Y0001745
  traceable to USP 1181302
storage temp.   room temp
SMILES string   OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
InChI   1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChI key   WQZGKKKJIJFFOK-DVKNGEFBSA-N

Description

General description

Dextrose belongs to the class of sugars, and is a preferred source of carbohydrate in parenteral nutrition regimens. It is widely used in solutions to adjust tonicity, as a sweetening agent, wet granulation diluent/binder, direct-compression tablet diluent/binder, etc. It is considered only for short term clinical use, since it is deficient in electrolytes.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Dextrose has been used as a standard in the determination of additives like glucose in beverages using high performance liquid chromatography (HPLC). It may also be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7785 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
LZ6600000

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Determination of Additives in Beverages Using Ascentis Express Columns

Beverages, such as sodas and energy drinks, can contain a number of polar ingredients, which are easily soluble in the water matrix of the drinks. These ingredients include sweeteners (sugars and sug...
Olga Shimelis, Hugh Cramer, and Michael D. Buchanan
US Reporter Volume 30.3
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Sample preparations, Separation, Vitamins

HPLC Analysis of Simple Underivatized Sugars on apHera™ NH2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Simple Underivatized Sugars on apHera™ NH2
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Sugars by HILIC Chromatography using Ascentis® Express OH-5 Column with ELSD Detection

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sugars by HILIC Chromatography using Ascentis® Express OH-5 Column with ELSD Detection
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Sugars on SUPELCOSIL™ LC-NH2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sugars on SUPELCOSIL™ LC-NH2
Keywords: Chromatography, High performance liquid chromatography

Sucrose Method for IdentificationTest B using silica gel G TLC plates

Sucrose is a common naturally occurring carbohydrate found in many plants and plant parts. The molecule is composed of two monosaccharides; glucose and fructose with the formula C12H22O11.
Dr Sanjay Poman
Merck KGaA, Darmstadt, Germany, Life Science Application Centre (GAC), Mumbai, India
Keywords: Separation, Thin layer chromatography

Thin Layer Chromatography Identification Test for Sucrose following European Pharmacopeia Monograph on Silica Gel G F 254 Plates

Sucrose is a common naturally occurring carbohydrate found in many plants and plant parts. The molecule is  composed of two monosaccharides; glucose and fructose with the formula C12H22O11.
Keywords: Separation, Thin layer chromatography

Peer-Reviewed Papers
15

References

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