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Aspirin (Acetyl Salicylic Acid)

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Acetylsalicylic acid, Aspirin

  • CAS Number 50-78-2

  • Linear Formula 2-(CH3CO2)C6H4CO2H

  • Molecular Weight 180.16

  •  Beilstein/REAXYS Number 779271

  •  EC Number 200-064-1

  •  MDL number MFCD00002430

  •  PubChem Substance ID 329823034

  •  NACRES NA.24

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Properties

Related Categories A-B, Acetylsalicylic acid / Aspirin, Additional Standards, Analytical Standards, Analytical/Chromatography,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   134-136 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 617
  traceable to PhEur A0200000
  traceable to USP 1044006
SMILES string   CC(=O)Oc1ccccc1C(O)=O
InChI   1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
InChI key   BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Gene Information   human ... PTGS1(5742), PTGS2(5743)

Description

General description

Aspirin (Acetyl Salicylic Acid) is a cyclo-oxygenase inhibitor and an antiplatelet agent, widely used for the secondary preventions of heart attack and stroke.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Aspirin (Acetyl Salicylic Acid) may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7669 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
VO0700000
Flash Point(F) 
482.0 °F
Flash Point(C) 
250 °C

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Antipyretics/Analgesics/Antifungals on Discovery® RP-AmideC16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antipyretics/Analgesics/Antifungals on Discovery® RP-AmideC16
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Aspirin and Salicylic Acid on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Aspirin and Salicylic Acid on Ascentis® Express RP-Amide
Keywords: Anti-inflammatory agents, Chromatography, High performance liquid chromatography, Metabolites, Pharmaceutical

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18
Keywords: Chromatography, High performance liquid chromatography, Vitamins

HPLC Analysis of Benzoic Acid Deriviatives on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzoic Acid Deriviatives on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Benzoic Acid and Related Compounds on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzoic Acid and Related Compounds on Ascentis® RP-Amide
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC Analysis of Pain Relievers on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Pain Relievers on Ascentis® Express C18
Keywords: Analgesics, Chromatography, Clinical, High performance liquid chromatography

HPLC Analysis of Salicylic Acid and Acetylsalicylic Acid (Aspirin) on Ascentis® Express OH5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Salicylic Acid and Acetylsalicylic Acid (Aspirin) on Ascentis® Express OH5
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

TLC Analysis Report of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis Report of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

TLC Analysis of Analgesics on HPTLC Pre-coated Plate RP-18 WF254s (analyte set 1)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Analgesics on HPTLC Pre-coated Plate RP-18 WF254s (analyte set 1)
Keywords: Pharmaceutical, Thin layer chromatography

TLC Analysis of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

Peer-Reviewed Papers
15

References

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