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PHR1004 Supelco

Ibuprofen

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 539
  traceable to PhEur I0020000
  traceable to USP 1335508
SMILES string   CC(C)Cc1ccc(cc1)C(C)C(O)=O
InChI   1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
InChI key   HEFNNWSXXWATRW-UHFFFAOYSA-N
Gene Information   human ... PTGS1(5742), PTGS2(5743)

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ibuprofen is a substituted arylpropionic acid, used as a non-steroidal anti-inflammatory drug (NSAID).

Application

Ibuprofen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.

Ibuprofen may be used as a standard in the quantitative determination of ibuprofen in samples of human plasma using high performance liquid chromatography (HPLC). It may also be used as a reference standard in the determination of ibuprofen in dog plasma using liquid chromatography (LC).

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0253 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
MU6640000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Acetaminophen, Caffeine, Chlorpheniramine, Ibuprofen, Naproxen, Phenylephrine, and Pseudoephedrine on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Acetaminophen, Caffeine, Chlorpheniramine, Ibuprofen, Naproxen, Phenylephrine, and Pseudoephedrine on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical, Separation

HPLC Analysis of Acidic and Neutral Drug Panel on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Acidic and Neutral Drug Panel on Ascentis® Express C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Hormones, Pharmaceutical

HPLC Analysis of Anti-Inflammatory Drugs on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Anti-Inflammatory Drugs on Discovery® RP-Amide C16
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Ibuprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ibuprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of NSAIDs on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of NSAIDs on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of NSAIDs on Discovery® Zr-Carbon C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of NSAIDs on Discovery® Zr-Carbon C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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