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PHR1005 Sigma-Aldrich

Acetaminophen

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 4′-Hydroxyacetanilide, 4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide, N-Acetyl-4-aminophenol, APAP, Paracetamol

  • CAS Number 103-90-2

  • Linear Formula CH3CONHC6H4OH

  • Molecular Weight 151.16

  •  Beilstein Registry Number 2208089

  •  EC Number 203-157-5

  •  MDL number MFCD00002328

  •  PubChem Substance ID 329823036

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Properties

Related Categories Acetaminophen / Paracetamol, Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography,
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   RZVAJINKPMORJF-UHFFFAOYSA-N
form   neat
mp   168-172 °C(lit.)
format   neat
pharmacopeia traceability   traceable to BP 371
  traceable to PhEur P030000
  traceable to USP 1003009

Description

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Application

Analgesic.

Acetaminophen may be used as a standard in the determination of acetaminophen in human serum or plasma samples using spectrophotometric technique. It may also be used as a standard in the estimation of acetaminophen in pharmaceutical formulations using high performance liquid chromatography (HPLC).

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

General description

Acetaminophen is a drug, which possesses pharmacological properties like antipyretic and analgesic property.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7782 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
1

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Protocols & Articles

Articles

HPLC Analysis of Acetaminophen, Caffeine, Chlorpheniramine, Ibuprofen, Naproxen, Phenylephrine, and Pseudoephedrine on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Acetaminophen, Caffeine, Chlorpheniramine, Ibuprofen, Naproxen, Phenylephrine, and Pseudoephedrine on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical, Separation

HPLC Analysis of Analgesics on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Analgesics on Ascentis® C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Analgesics on Discovery® HS F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Analgesics on Discovery® HS F5
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Analgesics on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Analgesics on Discovery® RP-Amide C16
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Antitussive/Antihistamine/Antipyretic Mix on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antitussive/Antihistamine/Antipyretic Mix on Discovery® RP-Amide C16
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Cold Remedy Components on Ascentis® Express 2.0 μm RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cold Remedy Components on Ascentis® Express 2.0 μm RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical, Separation

HPLC Analysis of Pain Relievers on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Pain Relievers on Ascentis® Express C18
Keywords: Analgesics, Chromatography, Clinical, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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