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PHR1008 Supelco

Ascorbic Acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: L-Ascorbic acid, L-Threoascorbic acid, Antiscorbutic factor, Vitamin C

  • CAS Number 50-81-7

  • Empirical Formula (Hill Notation) C6H8O6

  • Molecular Weight 176.12

  •  Beilstein/REAXYS Number 84272

  •  EC Number 200-066-2

  •  MDL number MFCD00064328

  •  PubChem Substance ID 329823039

  •  E Number E300

  •  NACRES NA.24

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Properties

Related Categories A-B, Analytical Standards, Analytical/Chromatography, E numbers (Food Additives), E300,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   190-194 °C (dec.)
Featured Industry   Cleaning Products
Cosmetics
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
Vitamins, Nutraceuticals, and Natural Products
pharmacopeia traceability   traceable to BP 461
  traceable to PhEur A1300000
  traceable to USP 1043003
SMILES string   OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O
InChI   1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
InChI key   CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Ascorbic acid is a powerful antioxidant and is widely used in pharmaceutical formulations. It has proven to have a beneficial effect on age-related diseases such as cancer, atherosclerosis, ocular, neurodegenerative diseases, etc. It is mainly involved in the formation and maintenance of collagen. The prolonged deficiency of ascorbic acid in diet may result in scurvy.

Application

Ascorbic Acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using hydrophilic interaction chromatography.

Biochem/physiol Actions

Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2886 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Assay and Organic Impurity Profiling of Droxidopa using a ZIC-HILIC column and UV detection

Droxidopa is a synthetic amino acid precursor, and acts as a prodrug to norepinephrine (noradrenaline) to increase neurotransmitter concentration in the body and the brain. Droxidopa was developed by...
Keywords: High performance liquid chromatography, Neurotransmitters, Pharmaceutical

HILIC Analysis of Polar Vitamins on Ascentis® Express OH5

From our library of Articles, Sigma-Aldrich presents HILIC Analysis of Polar Vitamins on Ascentis® Express OH5
Keywords: Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Ascorbic Acid on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ascorbic Acid on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Vitamins

HPLC Analysis of Vitamins, Water Soluble on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Vitamins, Water Soluble on Discovery® C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Vitamins, Water Soluble, on Discovery® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Vitamins, Water Soluble, on Discovery® C8
Keywords: Chromatography, High performance liquid chromatography, Vitamins

HPLC Analysis of Vitamins, Water Soluble, on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Vitamins, Water Soluble, on Discovery® RP-Amide C16
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Water Soluble Vitamins on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Water Soluble Vitamins on Ascentis® RP-Amide
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

Peer-Reviewed Papers
15

References

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