PHR1010 Supelco


Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 4-Hydroxybenzoic acid propyl ester, Propyl 4-hydroxybenzoate, Propyl paraben

  • CAS Number 94-13-3

  • Linear Formula HOC6H4CO2CH2CH2CH3

  • Molecular Weight 180.20

  •  Beilstein/REAXYS Number 1103245

  •  EC Number 202-307-7

  •  MDL number MFCD00002354

  •  PubChem Substance ID 329823041

  •  E Number E216

  •  NACRES NA.24



Related Categories Analytical Standards, Analytical/Chromatography, Antioxidants & Preservatives, Chinese Food Contact Materials Regulation GB 9685 2016, E numbers (Food Additives),
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   95-98 °C (lit.)
Featured Industry   Cleaning Products
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur P3650000
  traceable to USP 1577008
SMILES string   CCCOC(=O)c1ccc(O)cc1
InChI   1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3


General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Propylparaben is the benzoate ester, widely used as a preservative in personal care products.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAC2080 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
356.0 °F
Flash Point(C) 
180 °C


Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles


GC Analysis of Parabens on SLB®-5ms after SPME using 50/30 μm DVB/Carboxen/PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Parabens on SLB®-5ms after SPME using 50/30 μm DVB/Carboxen/PDMS Fiber
Keywords: Antimicrobials, Chromatography, Gas chromatography, Pharmaceutical, Purification, Solid phase microextractions

HPLC Analysis of Paraben Preservatives on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Paraben Preservatives on Discovery® C18
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

Qualification of Sunscreens Using Certified Reference Materials

Absorbing the sun’s rays helps the body create an important nutrient, Vitamin D, for immune system function and proper bone density. Exposing oneself to sunlight can have positive effects - setting t...
Keywords: Absorption, Cancer, Pharmaceutical, Vitamins

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?