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PHR1012 Supelco

Methylparaben

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: p-Hydroxybenzoic acid methyl ester, Methyl 4-hydroxybenzoate, Methyl paraben, NIPAGIN

  • CAS Number 99-76-3

  • Linear Formula HOC6H4CO2CH3

  • Molecular Weight 152.15

  •  Beilstein/REAXYS Number 509801

  •  EC Number 202-785-7

  •  MDL number MFCD00002352

  •  PubChem Substance ID 329823043

  •  E Number E218

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Antioxidants & Preservatives,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   125-128 °C (lit.)
Featured Industry   Cleaning Products
Cosmetics
Flavors and Fragrances
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur M1650000
  traceable to USP 1432005
SMILES string   COC(=O)c1ccc(O)cc1
InChI   1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3
InChI key   LXCFILQKKLGQFO-UHFFFAOYSA-N

Description

General description

Methylparaben is an antifungal and antibacterial agent, widely used as a preservative in cosmetics, pharmaceuticals, food and beverages.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Methylparaben may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase sequential injection chromatography (SIC) technique and high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0280 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
DH2450000
Flash Point(F) 
334.4 °F
Flash Point(C) 
168 °C

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

GC Analysis of Parabens on SLB®-5ms after SPME using 50/30 μm DVB/Carboxen/PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Parabens on SLB®-5ms after SPME using 50/30 μm DVB/Carboxen/PDMS Fiber
Keywords: Antimicrobials, Chromatography, Gas chromatography, Pharmaceutical, Purification, Solid phase microextractions

HPLC Analysis of Cosmetic Preservatives on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cosmetic Preservatives on Ascentis® Express RP-Amide
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC Analysis of Paraben Preservatives on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Paraben Preservatives on Discovery® C18
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC Analysis of Paraben Preservatives on Discovery® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Paraben Preservatives on Discovery® C8
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC Analysis of Paraben Preservatives on Discovery® Cyano

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Paraben Preservatives on Discovery® Cyano
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Paraben Preservatives on Discovery® RP-AmideC16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Paraben Preservatives on Discovery® RP-AmideC16
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

Qualification of Sunscreens Using Certified Reference Materials

Absorbing the sun’s rays helps the body create an important nutrient, Vitamin D, for immune system function and proper bone density. Exposing oneself to sunlight can have positive effects - setting t...
Keywords: Absorption, Cancer, Pharmaceutical, Vitamins

Related Content

Flavor and Fragrance Analysis

We offer quality product solutions in all three stages of analysis to help achieve fast, accurate results. Below, you can learn more about our workflow solutions for sample preparation, separation, d...
Keywords: Calorimetry, Chromatography, Environmental, Gas chromatography, Mass spectrometry, Pesticides, Sample preparations, Separation

Peer-Reviewed Papers
15

References

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