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Salicylic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2-Hydroxybenzoic acid

  • CAS Number 69-72-7

  • Linear Formula 2-(HO)C6H4CO2H

  • Molecular Weight 138.12

  •  Beilstein/REAXYS Number 774890

  •  EC Number 200-712-3

  •  MDL number MFCD00002439

  •  PubChem Substance ID 329823044

  •  NACRES NA.24

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Properties

Related Categories Acetylsalicylic Acid Metabolites, Additional Standards, Analytical Standards, Analytical/Chromatography, Aspirin (Acetylsalicyclic Acid) Impurities,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   4.8 (vs air)
vapor pressure   1 mmHg ( 114 °C)
InChI Key   YGSDEFSMJLZEOE-UHFFFAOYSA-N
form   neat
bp   211 °C (lit.)
mp   158-161 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 775
  traceable to PhEur S020000
  traceable to USP 1609002

Description

General description

Salicylic acid is an important material in pharmaceutical industry, obtained via the decomposition of acetylsalicylic acid. Salicylic acid is widely used in food industry for producing dyes and artificial scents. It also shows therapeutic potential in protecting the skin from sun damage and hence finds applications in cosmetics and medicine.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Salicylic acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrofluorometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3036 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
VO0525000
Flash Point(F) 
314.6 °F
Flash Point(C) 
157 °C
Protocols & Articles

Articles

HPLC Analysis Report of Organic Acids on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis Report of Organic Acids on Discovery® C18
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Antipyretics/Analgesics/Antifungals on Discovery® RP-AmideC16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antipyretics/Analgesics/Antifungals on Discovery® RP-AmideC16
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Aspirin and Salicylic Acid on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Aspirin and Salicylic Acid on Ascentis® Express RP-Amide
Keywords: Anti-inflammatory agents, Chromatography, High performance liquid chromatography, Metabolites, Pharmaceutical

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18
Keywords: Chromatography, High performance liquid chromatography, Vitamins

HPLC Analysis of Benzoic Acid Deriviatives on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzoic Acid Deriviatives on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Benzoic Acid and Related Compounds on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzoic Acid and Related Compounds on Ascentis® RP-Amide
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC Analysis of Diclofenac and Salicylic Acid on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Diclofenac and Salicylic Acid on Ascentis® C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Organic Acids on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Organic Acids on Discovery® C18
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Salicylic Acid and Acetylsalicylic Acid (Aspirin) on Ascentis® Express OH5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Salicylic Acid and Acetylsalicylic Acid (Aspirin) on Ascentis® Express OH5
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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