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PHR1035 Supelco

Folic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: PteGlu, Pteroyl-L-glutamic acid, Vitamin M

  • CAS Number 59-30-3

  • Empirical Formula (Hill Notation) C19H19N7O6

  • Molecular Weight 441.40

  •  Beilstein/REAXYS Number 100781

  •  EC Number 200-419-0

  •  MDL number MFCD00079305

  •  eCl@ss 34058014

  •  PubChem Substance ID 329823065

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, E-J, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur F0300000
  traceable to USP 1286005
SMILES string   NC1=NC(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2N1
InChI   1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
InChI key   OVBPIULPVIDEAO-LBPRGKRZSA-N

Description

General description

Folic acid is mostly obtained from the diet itself or from pharmaceutical drugs such as vitamin pills.† It is highly necessary to consume folic acid for the prevention of neural tube defects, mainly anencephaly and spina bifida.† It belongs to the class of water soluble B vitamins called folates. It is mainly used to fortify cereals/grains and dietary supplements.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Folic acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using ultraviolet spectrophotometric technique and microemulsion electrokinetic chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7352 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

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HPLC Analysis of Aminopterin and Related Compounds on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Aminopterin and Related Compounds on Ascentis® RP-Amide
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HPLC Analysis of B-vitamins on Ascentis® Express RP-Amide using UV detection

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of B-vitamins on Ascentis® Express RP-Amide using UV detection
Keywords: Anticonvulsants, Chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Vitamins, Water Soluble on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Vitamins, Water Soluble on Discovery® C18
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HPLC Analysis of Vitamins, Water Soluble, on Discovery® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Vitamins, Water Soluble, on Discovery® C8
Keywords: Chromatography, High performance liquid chromatography, Vitamins

HPLC Analysis of Vitamins, Water Soluble, on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Vitamins, Water Soluble, on Discovery® RP-Amide C16
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Water Soluble B Vitamins on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Water Soluble B Vitamins on Ascentis® Express RP-Amide
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Water-Soluble B-Vitamins on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Water-Soluble B-Vitamins on Ascentis® Express C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Water-Soluble B-Vitamins on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Water-Soluble B-Vitamins on Ascentis® Express F5
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

Thin Layer Chromatography Identification Test for Folic Acid following European Pharmacopeia Monograph on Silica Gel G F 254 Plates

Folic acid, known as folate in its natural form, is a water soluble compound known as vitamin B9. Folic acid is vital to the body in small amounts, and can found in whole-grain breads, cereals, liver...
Keywords: Solvents, Thin layer chromatography, Vitamins

UHPLC Analysis of B-vitamins on Titan™ C18 using UV detection

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of B-vitamins on Titan™ C18 using UV detection
Keywords: Anticonvulsants, Chromatography, Pharmaceutical, Vitamins

UHPLC Analysis of Methotrexate and Related Compounds on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Methotrexate and Related Compounds on Ascentis® Express C18
Keywords: Clinical, Pharmaceutical, Separation

Peer-Reviewed Papers
15

References

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