EMAIL THIS PAGE TO A FRIEND
PHR1040 Supelco

Naproxen

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid

  • CAS Number 22204-53-1

  • Linear Formula CH3OC10H6CH(CH3)CO2H

  • Molecular Weight 230.26

  •  Beilstein/REAXYS Number 3591068

  •  EC Number 244-838-7

  •  MDL number MFCD00010500

  •  PubChem Substance ID 329823070

  •  NACRES NA.24

Purchase

Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites,
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   CMWTZPSULFXXJA-VIFPVBQESA-N
form   neat
mp   152-154 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 435
  traceable to PhEur N0250000
  traceable to USP 1457301

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Naproxen belongs to the class of arylacetic acids and is used as a non-steroidal anti-inflammatory drug (NSAID). It is useful for the management of pain, inflammation and stiffness. It is also used in the treatment of rheumatoid arthritis and other painful musculoskeletal disorders.

Application

Naproxen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC) technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Non-selective cyclooxygenase (COX-1 and COX-2) inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8968 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
UF5275000

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of Acetaminophen, Caffeine, Chlorpheniramine, Ibuprofen, Naproxen, Phenylephrine, and Pseudoephedrine on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Acetaminophen, Caffeine, Chlorpheniramine, Ibuprofen, Naproxen, Phenylephrine, and Pseudoephedrine on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical, Separation

HPLC Analysis of Anti-Inflammatory Drugs on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Anti-Inflammatory Drugs on Discovery® RP-Amide C16
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of NSAIDs on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of NSAIDs on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of NSAIDs on Discovery® Zr-Carbon C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of NSAIDs on Discovery® Zr-Carbon C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Naproxen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Naproxen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?