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PHR1043 Supelco

Prednisolone

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrohydrocortisone, 1-Dehydrocortisol, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione

  • CAS Number 50-24-8

  • Empirical Formula (Hill Notation) C21H28O5

  • Molecular Weight 360.44

  •  Beilstein/REAXYS Number 1354103

  •  EC Number 200-021-7

  •  MDL number MFCD00003649

  •  PubChem Substance ID 329823073

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, P-S, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   OIGNJSKKLXVSLS-VWUMJDOOSA-N
form   neat
mp   240 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 464
  traceable to PhEur P2700000
  traceable to USP 1555005

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Prednisolone is a glucocorticoid utilized as an anti-inflammatory or an immunosuppressive drug.

Application

Prednisolone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Prednisolone may be used as a standard in the separation and determination of prednisolone in serum samples of animals using radioimmunoassay.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6903 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TU4152000

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Acidic and Neutral Drug Panel on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Acidic and Neutral Drug Panel on Ascentis® Express C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Hormones, Pharmaceutical

HPLC Analysis of Glucocorticoids on Ascentis® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Glucocorticoids on Ascentis® C8
Keywords: Chromatography, Clinical, High performance liquid chromatography, Hormones

HPLC Analysis of Prednisolone (Secondary Pharma Standard) on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Prednisolone (Secondary Pharma Standard) on Ascentis® C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Steroids on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® Express F5
Keywords: Chromatography, Clinical, High performance liquid chromatography

HPLC Analysis of Steroids on Ascentis® Si

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® Si
Keywords: Chromatography, Clinical, High performance liquid chromatography

UHPLC Analysis of Steroids on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Steroids on Ascentis® Express F5
Keywords: Separation

UHPLC/MS Analysis of Steroids on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Steroids on Titan™ C18
Keywords: Chromatography, Mass spectrometry, Pharmaceutical

Peer-Reviewed Papers
15

References

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