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PHR1045 Supelco

Diethylene glycol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2,2′-Oxydiethanol, 2-Hydroxyethyl ether, Bis(2-hydroxyethyl) ether, Diglycol

  • CAS Number 111-46-6

  • Linear Formula (HOCH2CH2)2O

  • Molecular Weight 106.12

  •  Beilstein/REAXYS Number 969209

  •  EC Number 203-872-2

  •  MDL number MFCD00002882

  •  PubChem Substance ID 329823075

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, C-D, Food and Cosmetic Component Standards, Pharmaceutical Secondary Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   2.14 (vs air)
vapor pressure   0.01 mmHg ( 20 °C)
autoignition temp.   442 °F
expl. lim.   2-12.3 %
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.447 (lit.)
bp   245 °C (lit.)
mp   −10 °C (lit.)
density   1.118 g/mL at 25 °C (lit.)
Featured Industry   Cleaning Products
Cosmetics
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur Y0000217
  traceable to USP 1193265
SMILES string   OCCOCCO
InChI   1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2
InChI key   MTHSVFCYNBDYFN-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.

Application

Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).

Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC). It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID).

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Kidney
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
ID5950000
Flash Point(F) 
289.4 °F - closed cup
Flash Point(C) 
143 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

GC Analysis of Glycols in Water on SPB®-1000 after SPE using ENVI-Carb™ Plus

From our library of Articles, Sigma-Aldrich presents GC Analysis of Glycols in Water on SPB®-1000 after SPE using ENVI-Carb™ Plus
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Sample preparations, Solid phase extractions

GC Analysis of Glycols on Nukol™

From our library of Articles, Sigma-Aldrich presents GC Analysis of Glycols on Nukol™
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

Peer-Reviewed Papers
15

References

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