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PHR1046 Supelco

Ethylene glycol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 1,2-Ethanediol

  • CAS Number 107-21-1

  • Linear Formula HOCH2CH2OH

  • Molecular Weight 62.07

  •  Beilstein/REAXYS Number 505945

  •  EC Number 203-473-3

  •  MDL number MFCD00002885

  •  eCl@ss 39020501

  •  PubChem Substance ID 329823076

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Chinese Food Contact Materials Regulation GB 9685 2016, E-J, Food & Beverage Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   2.1 (vs air)
vapor pressure   0.08 mmHg ( 20 °C)
form   neat
autoignition temp.   752 °F
expl. lim.   15.3 %
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.431 (lit.)
bp   195-198 °C
mp   −13 °C (lit.)
density   1.113 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1265515
SMILES string   OCCO
InChI   1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI key   LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Ethylene glycol can also be produced from fossil fuels (petroleum, natural gas and coal) and biomass-derived resources. It is a polyol having a wide range of industrial applications.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Ethylene glycol may be used as a standard in the determination of ethylene glycol present in serum samples using gas chromatography (GC).

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2089 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Target organs 
Kidney
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
WGK 1
RTECS 
KW2975000
Flash Point(F) 
239.0 °F - open cup
Flash Point(C) 
115 °C - open cup

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the molarity of ethylene glycol?
Ethylene glycol is 17.93M. This is calculated using the density (1.113 g/ml) and the molecular weight (62.07 g/mol). If the product is less than 100% pure,correct for the purity.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
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Protocols & Articles

Articles

GC Analysis of Class 2 Residual Solvents on OVI-G43

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on OVI-G43
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography

GC Analysis of Glycols and Diols on SPB®-1000

From our library of Articles, Sigma-Aldrich presents GC Analysis of Glycols and Diols on SPB®-1000
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Glycols in Water on SPB®-1000 after SPE using ENVI-Carb™ Plus

From our library of Articles, Sigma-Aldrich presents GC Analysis of Glycols in Water on SPB®-1000 after SPE using ENVI-Carb™ Plus
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Sample preparations, Solid phase extractions

GC Analysis of Glycols on Nukol™

From our library of Articles, Sigma-Aldrich presents GC Analysis of Glycols on Nukol™
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Residual Solvents on SPB®-1 SULFUR after SPME using 65 μm PDMS/DVB Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Residual Solvents on SPB®-1 SULFUR after SPME using 65 μm PDMS/DVB Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Purification, Solid phase microextractions

Peer-Reviewed Papers
15

References

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