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PHR1048 Supelco

4-Hydroxybenzoic acid

Pharmaceutical Secondary Standard; Certified Reference Material

  • CAS Number 99-96-7

  • Linear Formula HOC6H4CO2H

  • Molecular Weight 138.12

  •  Beilstein/REAXYS Number 970950

  •  EC Number 202-804-9

  •  MDL number MFCD00002547

  •  PubChem Substance ID 329823078

  •  NACRES NA.24

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Properties

Related Categories Acacia, Acid, Alcoholic & Nonalcoholic Beverages, All Alphabetically Sorted, Analytical Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   213-217 °C (lit.)
Featured Industry   Cleaning Products
Cosmetics
Flavors and Fragrances
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1609013
SMILES string   OC(=O)c1ccc(O)cc1
InChI   1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)
InChI key   FJKROLUGYXJWQN-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 4-Hydroxybenzoic acid belongs to the class of aromatic acids, which may be used as a preservative in cosmetics, pharmaceuticals and as a synthetic flavoring agent in food products.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB2176 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
DH1925000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18
Keywords: Chromatography, High performance liquid chromatography, Vitamins

HPLC Analysis of Benzoic Acid Deriviatives on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzoic Acid Deriviatives on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Benzoic Acid and Related Compounds on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzoic Acid and Related Compounds on Ascentis® RP-Amide
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

Related Content

Flavor and Fragrance Analysis

We offer quality product solutions in all three stages of analysis to help achieve fast, accurate results. Below, you can learn more about our workflow solutions for sample preparation, separation, d...
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Peer-Reviewed Papers
15

References

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