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PHR1067 Supelco

Carbamazepine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 5H-Dibenz[b,f]azepine-5-carboxamide

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, C-D, Carbamazepine,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   191-192 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 974
  traceable to PhEur C0450000
  traceable to USP 1093001
SMILES string   NC(=O)N1c2ccccc2C=Cc3ccccc13
InChI   1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
InChI key   FFGPTBGBLSHEPO-UHFFFAOYSA-N
Gene Information   human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Carbamazepine is a tricyclic lipophilic compound, with mild anticholinergic activity. It is widely used as an antiepileptic drug for the treatment of simple and complex partial tonic-clonic seizures.

Application

Carbamazepine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Sodium channel inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6055 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
HN8225000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Acidic and Neutral Drug Panel on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Acidic and Neutral Drug Panel on Ascentis® Express C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Hormones, Pharmaceutical

HPLC Analysis of Carbamazepine on Ascentis® Express ES-Cyano

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Carbamazepine on Ascentis® Express ES-Cyano
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

UHPLC/MS Analysis of Drugs in Whole Blood on Titan™ C18 after Biocompatible Solid Phase Microextraction (BioSPME) using SPME LC Tips with C18 °Chemistry

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Drugs in Whole Blood on Titan™ C18 after Biocompatible Solid Phase Microextraction (BioSPME) using SPME LC Tips with C18 °Chemistry
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Mass spectrometry, Sample preparations, Separation, Solid phase microextractions, Solvents

UHPLC/MS Analysis of Various Drug Substances on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Various Drug Substances on Titan™ C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

USP HPLC Analysis of Carbamazepine on an Ascentis® Express ES-CN Column

From our library of Articles, Sigma-Aldrich presents USP HPLC Analysis of Carbamazepine on an Ascentis® Express ES-CN Column
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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