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Ethylenediaminetetraacetic acid disodium salt dihydrate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate Disodium, Edetate disodium dihydrate, Edetate disodium salt dihydrate, Sequestrene Na2

  • CAS Number 6381-92-6

  • Empirical Formula (Hill Notation) C10H14N2Na2O8 · 2H2O

  • Molecular Weight 372.24

  •  Beilstein/REAXYS Number 3900609

  •  EC Number 205-358-3

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, E-J, Extractables and Leachables, Food & Beverage Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   248 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur D2900000
  traceable to USP 1233009
SMILES string   O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O
InChI   1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2
InChI key   OVBJJZOQPCKUOR-UHFFFAOYSA-L

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Ethylenediaminetetraacetic acid disodium salt dehydrate may be used as a reference standard in validating the potential antioxidant activity and the total phenolic content of samples of seaweed extract via metal chelation technique using ferrous ion-chelating ability assay.

Ethylenediaminetetraacetic acid disodium salt dihydrate may be used as a pharmaceutical reference standard for the determination of ethylenediaminetetraacetic acid (EDTA) in pharmaceutical formulations using ion chromatography with suppressed conductimetric detection.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA5634 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory Tract
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
AH4410000
Flash Point(F) 
No data available
Flash Point(C) 
No data available

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Qualification of Sunscreens Using Certified Reference Materials

Absorbing the sun’s rays helps the body create an important nutrient, Vitamin D, for immune system function and proper bone density. Exposing oneself to sunlight can have positive effects - setting t...
Keywords: Absorption, Cancer, Pharmaceutical, Vitamins

Peer-Reviewed Papers
15

References

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