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PHR1074 Supelco

Oxybenzone

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2-Hydroxy-4-methoxybenzophenone, Oxybenzone

  • CAS Number 131-57-7

  • Linear Formula HOC6H3(OCH3)COC6H5

  • Molecular Weight 228.24

  •  Beilstein/REAXYS Number 1913145

  •  EC Number 205-031-5

  •  MDL number MFCD00008387

  •  eCl@ss 39023842

  •  PubChem Substance ID 329823097

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
bp   150-160 °C/5 mmHg (lit.)
mp   62-64 °C (lit.)
Featured Industry   Environmental
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1485001
SMILES string   COc1ccc(c(O)c1)C(=O)c2ccccc2
InChI   1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3
InChI key   DXGLGDHPHMLXJC-UHFFFAOYSA-N

Description

General description

Oxybenzone, also known as benzophenone-3, belongs to the class of aromatic organic UV filters. It is categorized as an endocrine disruptor chemical (EDC) as it can interfere with the endocrine system. It exhibits estrogenic activity through its interaction with the estrogen receptors alpha (ERα) and beta (ERβ). It is a lipophilic, broad-spectrum sunscreen agent which absorbs ultraviolet B (290−320 nm), some ultraviolet A (320−360 nm), and some ultraviolet C (250−290 nm) radiations. It is widely used as an active compound in commercial sunscreens, creams, lotions, lipsticks, perfumes, shower bath, hair sprays, shampoos, and transparent packing material of products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Oxybenzone may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3268 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
DJ1575000
Flash Point(F) 
212.0 °F - closed cup
Flash Point(C) 
100 °C - closed cup
Protocols & Articles

Articles

Qualification of Sunscreens Using Certified Reference Materials

Absorbing the sun’s rays helps the body create an important nutrient, Vitamin D, for immune system function and proper bone density. Exposing oneself to sunlight can have positive effects - setting t...
Keywords: Absorption, Cancer, Pharmaceutical, Vitamins

Peer-Reviewed Papers
15

References

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