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PHR1078 Supelco

Phytonadione

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Phytomenadione, Vitamin K1(20), Vitamin K1

  • CAS Number 84-80-0

  • Empirical Formula (Hill Notation) C31H46O2

  • Molecular Weight 450.70

  •  Beilstein/REAXYS Number 2568816

  •  EC Number 201-564-2

  •  MDL number MFCD00214063

  •  PubChem Substance ID 329823101

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, P-S, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   MBWXNTAXLNYFJB-NKFFZRIASA-N
form   neat
storage condition   protect from light
refractive index   n20/D 1.527 (lit.)
mp   −20 °C (lit.)
density   0.984 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 423
  traceable to PhEur P1609000
  traceable to USP 1538006
storage temp.   2-8°C
SMILES string   O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O

Description

General description

Phytonadione belongs to the category of oral anticonvulsant drugs. It protects a newborn from acquiring hemorrhagic diseases by maintaining a normal blood clotting mechanism.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Phytonadione may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3714 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
Flash Point(F) 
>235.4 °F
Flash Point(C) 
>113 °C

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of Fat Soluble Vitamins on Ascentis® Express RP-Amide, Acetonitrile Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fat Soluble Vitamins on Ascentis® Express RP-Amide, Acetonitrile Mobile Phase
Keywords: Chromatography, High performance liquid chromatography, Vitamins

HPLC Analysis of Fat Soluble Vitamins on Ascentis® Express RP-Amide, Methanol Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fat Soluble Vitamins on Ascentis® Express RP-Amide, Methanol Mobile Phase
Keywords: Chromatography, High performance liquid chromatography, Vitamins

HPLC Analysis of Fat-Soluble Vitamins on Ascentis® Express C18, Methanol Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fat-Soluble Vitamins on Ascentis® Express C18, Methanol Mobile Phase
Keywords: Chromatography, High performance liquid chromatography, Vitamins

UHPLC Analysis of Vitamin K1 and Related Compound on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Vitamin K1 and Related Compound on Ascentis® Express C18
Keywords: Chromatography, Vitamins

UHPLC/MS Analysis of Vitamin K1 and Related Compound on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Vitamin K1 and Related Compound on Ascentis® Express C18
Keywords: Chromatography, Clinical, Mass spectrometry, Vitamins

Peer-Reviewed Papers
15

References

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