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PHR1091 Supelco

Vanillin melting point standard

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 4-Hydroxy-3-methoxybenzaldehyde, Vanillic aldehyde, Vanillin

  • CAS Number 121-33-5

  • Linear Formula 4-(HO)C6H3-3-(OCH3)CHO

  • Molecular Weight 152.15

  •  Beilstein/REAXYS Number 472792

  •  EC Number 204-465-2

  •  MDL number MFCD00006942

  •  PubChem Substance ID 329823113

  •  NACRES NA.24



Related Categories All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Flavors and Fragrance Standards, Food & Beverage Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   5.3 (vs air)
vapor pressure   >0.01 mmHg ( 25 °C)
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
bp   170 °C/15 mmHg (lit.)
mp   ~Approximately 82 °C
  81-83 °C (lit.)
Featured Industry   Cleaning Products
Flavors and Fragrances
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1711009
SMILES string   COc1cc(C=O)ccc1O
InChI   1S/C8H8O3/c1-11-8-4-6(5-9)2-3-7(8)10/h2-5,10H,1H3


General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Vanillin Melting Point Standard also called Vanillin is an aromatic compound, and is used for flavoring foods. It is has biogenetic relationship to phenylpropanoid pathway. It is mostly used in foods, beverages, perfumes and pharmaceuticals.


It has been used as reference standard in calibrating hot stage; during thermomicroscopic investigation performed with optical polarizing microscope; usually equipped with a hot stage and temperature controller.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAB1953 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
307.4 °F - closed cup
Flash Point(C) 
153 °C - closed cup
Protocols & Articles

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