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PHR1099 Supelco

L-Isoleucine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: (2S,3S)-2-Amino-3-methylpentanoic acid

  • CAS Number 73-32-5

  • Linear Formula C2H5CH(CH3)CH(NH2)CO2H

  • Molecular Weight 131.17

  •  Beilstein/REAXYS Number 1721792

  •  EC Number 200-798-2

  •  MDL number MFCD00064222

  •  eCl@ss 32160406

  •  PubChem Substance ID 329823121

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, E-J, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   AGPKZVBTJJNPAG-WHFBIAKZSA-N
form   neat
mp   288 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur I0460000
  traceable to USP 1349502
storage temp.   2-8°C

Description

General description

L-Isoleucine is an isomer of L-leucine and an essential amino acid. It is synthesized from threonine and is a branched-chain hydrophobic amino acid.

Application

L-Isoleucine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7132 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

GC Analysis of Amino Acids (as TBDMS Derivatives) on SLB®-5ms (20 m x 0.18 mm I.D., 0.18 μm), Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents GC Analysis of Amino Acids (as TBDMS Derivatives) on SLB®-5ms (20 m x 0.18 mm I.D., 0.18 μm), Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Purification

HPLC Analysis of Isoleucine Enantiomers on Astec® CHIROBIOTIC® T (25 °C )

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Isoleucine Enantiomers on Astec® CHIROBIOTIC® T (25 °C )
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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