PHR1114 Supelco

Stearic Acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 1-Heptadecanecarboxylic acid, C18:0, Cetylacetic acid, NSC 25956, NSC 261168, Octadecanoic acid, Stearic acid, Stearophanic acid

  • CAS Number 57-11-4

  • Linear Formula CH3(CH2)16COOH

  • Molecular Weight 284.48

  •  Beilstein/REAXYS Number 608585

  •  EC Number 200-313-4

  •  MDL number MFCD00002752

  •  PubChem Substance ID 329823135



Related Categories Analytical Standards, Analytical/Chromatography, Chinese Food Contact Materials Regulation GB 9685 2016, Extractables and Leachables, Food & Beverage Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor pressure   1 mmHg ( 173.7 °C)
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
bp   361 °C (lit.)
mp   67-72 °C (lit.)
Featured Industry   Cleaning Products
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur S1340000
  traceable to USP 1621008
InChI   1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)


General description

Stearic acid is a saturated fatty acid, which is a long aliphatic chain containing a carboxyl group at one end and a methyl group at the other. Pharmaceutically, it is used as a lubricant in tablet and capsule formulations and as an emulsifying and solubilizing agent in topical formulations.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


Stearic acid may be used as a pharmaceutical reference standard for the determination of the analyte in raw material, food and pharmaceutical formulations by gas chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAA7125 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Protocols & Articles


HPLC Analysis of Fatty Acids on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fatty Acids on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Free Fatty Acids on SUPELCOSIL™ LC-8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Free Fatty Acids on SUPELCOSIL™ LC-8
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers


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