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Butylated Hydroxytoluene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

  • CAS Number 128-37-0

  • Linear Formula [(CH3)3C]2C6H2(CH3)OH

  • Molecular Weight 220.35

  •  Beilstein/REAXYS Number 1911640

  •  EC Number 204-881-4

  •  MDL number MFCD00011644

  •  PubChem Substance ID 329823138

  •  E Number E321

  •  NACRES NA.24

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Properties

Related Categories A-B, Analytical Standards, Analytical/Chromatography, Antioxidants, Antioxidants & Preservatives,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   7.6 (vs air)
vapor pressure   <0.01 mmHg ( 20 °C)
form   neat
autoignition temp.   878 °F
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
bp   265 °C (lit.)
mp   69-73 °C (lit.)
Featured Industry   Cleaning Products
Cosmetics
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur B1215000
  traceable to USP 1092708
SMILES string   Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
InChI   1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3
InChI key   NLZUEZXRPGMBCV-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Butylated hydroxytoluene (BHT) is a phenolic antioxidant used as a food additive. It is frequently added to dried cereals, cooking oils and animal foods. BHT is also known to enhance the stability of pharmaceuticals, fat-soluble vitamins and cosmetics .

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3695 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 2
Flash Point(F) 
No data available
Flash Point(C) 
No data available
Protocols & Articles

Articles

HPLC Analysis of Phenolic Antioxidants on Ascentis® Express C18 2.7 μm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Phenolic Antioxidants on Ascentis® Express C18 2.7 μm
Keywords: Chromatography, Degradations, High performance liquid chromatography

HPLC Analysis of Phenolic Antioxidants on Ascentis® Express C18 5 μm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Phenolic Antioxidants on Ascentis® Express C18 5 μm
Keywords: Degradations, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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