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PHR1118 Supelco

Propyl gallate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 3,4,5-Trihydroxybenzoic acid propyl ester

  • CAS Number 121-79-9

  • Linear Formula 3,4,5-(HO)3C6H2CO2CH2CH2CH3

  • Molecular Weight 212.20

  •  Beilstein/REAXYS Number 1877976

  •  EC Number 204-498-2

  •  MDL number MFCD00002196

  •  PubChem Substance ID 329823139

  •  E Number E310

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Properties

Related Categories Additional Standards, All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Antioxidants,
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   ZTHYODDOHIVTJV-UHFFFAOYSA-N
form   neat
mp   146-149 °C (lit.)
Featured Industry   Cosmetics, Personal Care, and Cleaning Products
Food and Beverages
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur P3640000
  traceable to USP 1576800

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.

Biochem/physiol Actions

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

Reconstitution

Prepare a 0.1M solution in glycerol:PBS (9:1)

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8981 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
Flash Point(F) 
368.6 °F
Flash Point(C) 
187 °C

Documents

Certificate of Analysis

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Protocols & Articles

Articles

GC Analysis of Antioxidants on SAC™-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Antioxidants on SAC™-5
Keywords: Chromatography, Cosmetics, Flame ionization detector, Gas chromatography, Purification

HPLC Analysis of Antioxidants on SUPELCOSIL™ LC-18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antioxidants on SUPELCOSIL™ LC-18
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

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Peer-Reviewed Papers
15

References

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