EMAIL THIS PAGE TO A FRIEND
PHR1118 Supelco

Propyl gallate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 3,4,5-Trihydroxybenzoic acid propyl ester

  • CAS Number 121-79-9

  • Linear Formula 3,4,5-(HO)3C6H2CO2CH2CH2CH3

  • Molecular Weight 212.20

  •  Beilstein/REAXYS Number 1877976

  •  EC Number 204-498-2

  •  MDL number MFCD00002196

  •  PubChem Substance ID 329823139

  •  E Number E310

  •  NACRES NA.24

Purchase

Properties

Related Categories Additional Standards, All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Antioxidants,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   146-149 °C (lit.)
Featured Industry   Cleaning Products
Cosmetics
Flavors and Fragrances
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur P3640000
  traceable to USP 1576800
SMILES string   CCCOC(=O)c1cc(O)c(O)c(O)c1
InChI   1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3
InChI key   ZTHYODDOHIVTJV-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Propyl gallate is a synthetic phenolic antioxidant (SPA) utilized in food additives to inhibit or regulate the lipid oxidation. SPAs are cost-effective, largely available and highly efficient in comparison to their natural counterparts.

Application

Propyl gallate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and fatty liquids by chromatography and spectrophotometry.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.

Biochem/physiol Actions

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

Reconstitution

Prepare a 0.1M solution in glycerol:PBS (9:1)

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8981 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
368.6 °F - closed cup
Flash Point(C) 
187 °C - closed cup

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

GC Analysis of Antioxidants on SAC™-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Antioxidants on SAC™-5
Keywords: Chromatography, Cosmetics, Flame ionization detector, Gas chromatography, Purification

HPLC Analysis of Antioxidants on SUPELCOSIL™ LC-18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antioxidants on SUPELCOSIL™ LC-18
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

Related Content

Flavor and Fragrance Analysis

We offer quality product solutions in all three stages of analysis to help achieve fast, accurate results. Below, you can learn more about our workflow solutions for sample preparation, separation, d...
Keywords: Calorimetry, Chromatography, Environmental, Gas chromatography, Mass spectrometry, Pesticides, Sample preparations, Separation

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?