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L-Glutamine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: (S)-2,5-Diamino-5-oxopentanoic acid, L-Glutamic acid 5-amide, Levoglutamide

  • CAS Number 56-85-9

  • Linear Formula H2NCOCH2CH2CH(NH2)CO2H

  • Molecular Weight 146.14

  •  Beilstein/REAXYS Number 1723797

  •  EC Number 200-292-1

  •  MDL number MFCD00008044

  •  PubChem Substance ID 329823146

  •  NACRES NA.24

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Properties

Related Categories All Alphabetically Sorted, Amino Acids, Analytical Standards, Analytical/Chromatography, E-J,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   185 °C (dec.) (lit.)
Featured Industry   Cleaning Products
Cosmetics
Flavors and Fragrances
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1294808
SMILES string   N[C@@H](CCC(N)=O)C(O)=O
InChI   1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChI key   ZDXPYRJPNDTMRX-VKHMYHEASA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-glutamine is the most abundant amino acid in the body. It is essential for the synthesis of L-asparagine. It also helps in muscle growth through protein synthesis and increased growth hormone levels.

Application

L-Glutamine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using amperometric L-glutamate oxidase based enzyme sensors.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7149 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

GC Analysis of Amino Acids (as TBDMS Derivatives) on SLB®-5ms (20 m x 0.18 mm I.D., 0.18 μm), Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents GC Analysis of Amino Acids (as TBDMS Derivatives) on SLB®-5ms (20 m x 0.18 mm I.D., 0.18 μm), Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Purification

HPLC Analysis of Glutamine Enantiomers on Astec® CHIROBIOTIC® T

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Glutamine Enantiomers on Astec® CHIROBIOTIC® T
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Polar Neutral and Acidic Amino Acids on Ascentis® Si (Silica)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Polar Neutral and Acidic Amino Acids on Ascentis® Si (Silica)
Keywords: Chromatography, High performance liquid chromatography

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Peer-Reviewed Papers
15

References

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