PHR1136 Supelco


Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2-Methoxyphenol, Catechol monomethyl ether, Pyrocatechol monomethyl ether

  • CAS Number 90-05-1

  • Linear Formula (CH3O)C6H4OH

  • Molecular Weight 124.14

  •  Beilstein/REAXYS Number 508112

  •  EC Number 201-964-7

  •  MDL number MFCD00002185

  •  PubChem Substance ID 329823156

  •  NACRES NA.24



Related Categories Additional Standards, Alcoholic & Nonalcoholic Beverages, All Alphabetically Sorted, Alphabetical Index of Phytochemical Standards, Analytical Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   4.27 (vs air)
vapor pressure   0.11 mmHg ( 25 °C)
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.543 (lit.)
bp   205 °C (lit.)
mp   26-29 °C (lit.)
density   1.129 g/mL at 25 °C (lit.)
Featured Industry   Cleaning Products
Flavors and Fragrances
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur Y0000619
  traceable to USP 1300004
SMILES string   COc1ccccc1O
InChI   1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3


General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


Guaiacol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC) and electroanalytical techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Guaiacol, along with 2,4,6-trichloroanisole, is responsible for cork taint in wine. A method has been developed for extraction and quantitation of the two compounds.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAB3328 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
179.6 °F - closed cup
Flash Point(C) 
82 °C - closed cup
Protocols & Articles


HPLC Analysis of Guaifenesin and Impurity A and B on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Guaifenesin and Impurity A and B on Ascentis® Express C18
Keywords: High performance liquid chromatography, Pharmaceutical

Vanilla – Natural or Out of the Reaction Flask

Vanilla is one of the most popular flavors in food and beverage products. The demand far exceeds the global supply of naturally grown vanilla; therefore, in addition to natural vanilla, artificial va...
Keywords: Food & Beverage, High performance liquid chromatography, Indicators, Sample preparations

Related Content

Flavor and Fragrance Analysis

We offer quality product solutions in all three stages of analysis to help achieve fast, accurate results. Below, you can learn more about our workflow solutions for sample preparation, separation, d...
Keywords: Calorimetry, Chromatography, Environmental, Gas chromatography, Mass spectrometry, Pesticides, Sample preparations, Separation

Peer-Reviewed Papers


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