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PHR1138 Supelco

Adenosine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 9-β-D-Ribofuranosyladenine, Adenine riboside, Adenine-9-β-D-ribofuranoside

  • CAS Number 58-61-7

  • Empirical Formula (Hill Notation) C10H13N5O4

  • Molecular Weight 267.24

  •  Beilstein/REAXYS Number 93029

  •  EC Number 200-389-9

  •  MDL number MFCD00005752

  •  PubChem Substance ID 329823158

  •  NACRES NA.24

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Properties

Related Categories A-B, Analytical Standards, Analytical/Chromatography, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   OIRDTQYFTABQOQ-KQYNXXCUSA-N
form   neat
mp   234-236 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur A0230200
  traceable to USP 1012123
storage temp.   2-8°C

Description

General description

Adenosine is a purine nucleoside and a building block of RNA and many other biomolecules such as adenosine triphosphate and nicotinamide adenine dinucleotide. In the extracellular space, ecto-5′-nucleotidase (CD73) dephosphorylates adenosine triphosphate (ATP) to produce adenosine. Adenosine has four receptors namely A1R, A2AR A2BR and A3R. Adenosine plays a key role in the osteogenic differentiation. A1R induces osteoclast differentiation and A2AR induces osteoblast differentiation.

Application

Adenosine may be used as a pharmaceutical reference standard for the quantification of the analyte in infusion solutions using high-performance liquid chromatography technique and capillary electrophoresis.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7134 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Nucleosides on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Nucleosides on Ascentis® Express HILIC
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Nucleosides on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Nucleosides on Ascentis® Phenyl
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Nucleosides on Ascentis® Si (Silica)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Nucleosides on Ascentis® Si (Silica)
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Nucleotides on SUPELCOSIL™ LC-18-T

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Nucleotides on SUPELCOSIL™ LC-18-T
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Ribonucleosides on Ascentis® Si

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ribonucleosides on Ascentis® Si
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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