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Tributyl 2-acetylcitrate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Acetyl tributyl citrate

  • CAS Number 77-90-7

  • Linear Formula CH3CO2C[CO2(CH2)3CH3][CH2CO2(CH2)3CH3]2

  • Molecular Weight 402.48

  •  Beilstein/REAXYS Number 2303316

  •  EC Number 201-067-0

  •  MDL number MFCD00043554

  •  PubChem Substance ID 329823174

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Chinese Food Contact Materials Regulation GB 9685 2016, Food & Beverage Standards, Food Contact Materials,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor pressure   0.26 psi ( 20 °C)
  0.8 psi ( 55 °C)
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.443 (lit.)
density   1.05 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur Y0001055
  traceable to USP 1009901
SMILES string   CCCCOC(=O)CC(CC(=O)OCCCC)(OC(C)=O)C(=O)OCCCC
InChI   1S/C20H34O8/c1-5-8-11-25-17(22)14-20(28-16(4)21,19(24)27-13-10-7-3)15-18(23)26-12-9-6-2/h5-15H2,1-4H3
InChI key   QZCLKYGREBVARF-UHFFFAOYSA-N

Description

General description

Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Tributyl 2-acetylcitrate may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8991 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
422.6 °F - closed cup
Flash Point(C) 
217 °C - closed cup

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

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