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PHR1167 Supelco

Ciprofloxacin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid, Ciprobay

  • CAS Number 85721-33-1

  • Empirical Formula (Hill Notation) C17H18FN3O3

  • Molecular Weight 331.34

  •  Beilstein/REAXYS Number 3568352

  •  MDL number MFCD00185755

  •  PubChem Substance ID 329823184

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, C-D, Chromatography,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur Y0000198
  traceable to USP 1134313
SMILES string   OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O
InChI   1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
InChI key   MYSWGUAQZAJSOK-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ciprofloxacin is grouped under the class of second generation of quinolone analogs of nalidixic acid that exhibits high potency, minimal toxicity and a broad-spectrum antibacterial activity. It can be administered both parenterally and orally. It finds applications in the treatment of broad range of infections of the urinary tract, respiratory tract and gastrointestinal tract, as well as skin and soft tissue infections.

Application

Ciprofloxacin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and serum samples by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Values of analytes vary lot to lot.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6508 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of Antibacterials/Antifungals on Ascentis® RP-Amide, Phosphate Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antibacterials/Antifungals on Ascentis® RP-Amide, Phosphate Mobile Phase
Keywords: Antibiotics, Antifungals, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Antibiotics (Fluoroquinolones from Tablets) on Discovery® HS C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antibiotics (Fluoroquinolones from Tablets) on Discovery® HS C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Antibiotics on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antibiotics on Discovery® C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Fluoroquinolone Antibiotics on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluoroquinolone Antibiotics on Ascentis® Express C18
Keywords: Antibiotics, Chromatography, High performance liquid chromatography

HPLC Analysis of Fluoroquinolone Antibiotics on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluoroquinolone Antibiotics on Ascentis® Phenyl
Keywords: Antibiotics, Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical

HPLC Analysis of Fluroquinolone Antibiotics on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluroquinolone Antibiotics on Discovery® C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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