• USA Home
  • PHR1182 - Papaverine hydrochloride

PHR1182 Supelco

Papaverine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride

  • CAS Number 61-25-6

  • Empirical Formula (Hill Notation) C20H21NO4 · HCl

  • Molecular Weight 375.85

  •  Beilstein/REAXYS Number 3921435

  •  EC Number 200-502-1

  •  MDL number MFCD00012745

  •  PubChem Substance ID 329823194

  •  NACRES NA.24



Related Categories Alphabetical Index of Phytochemical Standards, Analytical Standards, Analytical/Chromatography, N - R, P-S,
grade   certified reference material
  pharmaceutical secondary standard
form   neat
Featured Industry   Food and Beverages
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 277
  traceable to PhEur P0270000
  traceable to USP 1496008


General description

Papaverine hydrochloride is the hydrochloride salt of an opiate derivative called papaverine, a benzylisoquinoline compound. It has been found to relax smooth muscles of blood vessels and is used in the management of occlusivity and spasticity of pulmonary, coronary and peripheral arteries.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


Papaverine hydrochloride is used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAA9001 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles


UHPLC/MS Analysis of Heroin and Related Compounds on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Heroin and Related Compounds on Titan™ C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?