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PHR1204 Supelco

Benzophenone

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Diphenyl ketone, Diphenylmethanone, NSC 8077

  • CAS Number 119-61-9

  • Linear Formula (C6H5)2CO

  • Molecular Weight 182.22

  •  Beilstein/REAXYS Number 1238185

  •  EC Number 204-337-6

  •  MDL number MFCD00003076

  •  PubChem Substance ID 329823211

  •  NACRES NA.24

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Properties

Related Categories A-B, A-F, Additional Standards, All Alphabetically Sorted, Analytical Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor pressure   1 mmHg ( 108 °C)
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
bp   305 °C (lit.)
mp   47-51 °C (lit.)
Featured Industry   Cleaning Products
Cosmetics
Flavors and Fragrances
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur Y0000647
SMILES string   O=C(C1=CC=CC=C1)C2=CC=CC=C2
InChI   1S/C13H10O/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H
InChI key   RWCCWEUUXYIKHB-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Benzophenone is widely used in the manufacture of cosmetics and pharmaceuticals for its UV rays absorbing and fragrance retention abilities. Due to its ability to absorb ultraviolet radiations harmful in the form of UVA (320-400 nm) and UVB (290-320 nm), it is effective against skin disorders and skin cancer. It is used in the synthesis of antihistamines, hypnotics, and insecticides and is present as a potential impurity in diphenhydramine hydrochloride, phenytoin bulk powder, and phenytoin dosage forms.

Application

Benzophenone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic, spectrophotometric and polarographic techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3932 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 1
RTECS 
RTECS
Flash Point(F) 
280.4 °F - closed cup
Flash Point(C) 
138 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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Peer-Reviewed Papers
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