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PHR1218 Supelco

trans-Anethole

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 4-Propenylanisole, trans-1-Methoxy-4-(1-propenyl)benzene

  • CAS Number 4180-23-8

  • Linear Formula CH3CH=CHC6H4OCH3

  • Molecular Weight 148.20

  •  Beilstein/REAXYS Number 774229

  •  EC Number 224-052-0

  •  MDL number MFCD00009284

  •  PubChem Substance ID 329823225

  •  NACRES NA.24

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Properties

Related Categories A-B, Analytical Standards, Analytical/Chromatography, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.561 (lit.)
bp   234-237 °C (lit.)
mp   20-21 °C (lit.)
density   0.988 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1035005
SMILES string   COc1ccc(\C=C\C)cc1
InChI   1S/C10H12O/c1-3-4-9-5-7-10(11-2)8-6-9/h3-8H,1-2H3/b4-3+
InChI key   RUVINXPYWBROJD-ONEGZZNKSA-N

Description

General description

trans-Anethole is an aromatic monoterpenoid compound and derivative of phenylpropene. It is predominantly used as a fragrance in cosmetics and as a flavoring agent in food and pharmaceutical industries.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

trans-Anethole may be used as an analytical reference standard for the determination of the analyte in raw material, food products and pharmaceutical formulations by high performance liquid chromatography and gas chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Naturally occurring phenylpropene derivative that is estrogenic at lower concentrations and cytotoxic at higher concentrations to cancer cell lines. The cytotoxicity is related to the metabolism of trans-anethole to 4-hydroxy-1-propenylbenzene.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3326 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
BZ9275000
Flash Point(F) 
213.8 °F
Flash Point(C) 
101 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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