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PHR1239 Supelco

β-Carotene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: β,β-Carotene, Provitamin A

  • CAS Number 7235-40-7

  • Empirical Formula (Hill Notation) C40H56

  • Molecular Weight 536.87

  •  Beilstein/REAXYS Number 1917416

  •  EC Number 230-636-6

  •  MDL number MFCD00001556

  •  PubChem Substance ID 329823244

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, All alphabetical sorted, Analytical Standards, Analytical/Chromatography, C-D,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Cleaning Products
Cosmetics
Food and Beverages
Personal Care
Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1065480
SMILES string   CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)(C)CCC1
InChI   1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+
InChI key   OENHQHLEOONYIE-JLTXGRSLSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
β-Carotene is an antioxidant and is one of the most important carotenoids and a source of vitamin A. It is abundantly present in fruits and vegetables which is also used as a food supplement and a colorant.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

β-Carotene may be used as a pharmaceutical reference standard for the determination of the analyte in serum, plasma samples, fruits and vegetables by various chromatography techniques.

Biochem/physiol Actions

The most important of the provitamins A, β-carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0284 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
FI0329500
Flash Point(F) 
217.9 °F - closed cup - Not applicable
Flash Point(C) 
103.3 °C - closed cup - Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Carotene Compounds on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Carotene Compounds on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Vitamins

LC-MS Analysis of Carotene Compounds on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents LC-MS Analysis of Carotene Compounds on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Vitamins

Peer-Reviewed Papers
15

References

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