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Procainamide hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 4-Amino-N-(2-diethylaminoethyl)benzamide hydrochloride, 4-Aminobenzoic acid 2-diethylaminoethylamide

  • CAS Number 614-39-1

  • Linear Formula H2NC6H4CONHCH2CH2N(C2H5)2·HCl

  • Molecular Weight 271.79

  •  Beilstein/REAXYS Number 3729517

  •  EC Number 210-381-7

  •  MDL number MFCD00012998

  •  PubChem Substance ID 329823255

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, P-S, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   167-169 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur P3050000
  traceable to USP 1563502
SMILES string   Cl.CCN(CC)CCNC(=O)c1ccc(N)cc1
InChI   1S/C13H21N3O.ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);1H
InChI key   ABTXGJFUQRCPNH-UHFFFAOYSA-N
Gene Information   human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

General description

Procainamide hydrochloride belongs to the class I of antiarrhythmic drugs and is used for the management of heart arrhythmia in cardiac patients. It is also proposed to exhibit chemoprotective behavior against cisplatin-induced kidney toxicity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Procainamide hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical preparations by spectrophotometric and electrophoretic techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC4012 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Procainamide and N-Acetylprocainamide on Discovery® HS F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Procainamide and N-Acetylprocainamide on Discovery® HS F5
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

LC/MS Analysis of Anesthetics on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Anesthetics on Ascentis® Express F5
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical

LC/MS Analysis of Antiarrhythmics on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antiarrhythmics on Ascentis® Express Biphenyl
Keywords: High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

LC/MS Analysis of Cardiac Depressants on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Cardiac Depressants on Ascentis® Express Biphenyl
Keywords: High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

Peer-Reviewed Papers
15

References

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