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PHR1272 Supelco

Maleic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: cis-Butenedioic acid, Toxilic acid

  • Linear Formula HO2CCH=CHCO2H

  • Molecular Weight 116.07

  •  Beilstein/REAXYS Number 605762

  •  EC Number 203-742-5

  •  MDL number MFCD00063177

  •  PubChem Substance ID 329823268

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Chinese Food Contact Materials Regulation GB 9685 2016, Food & Beverage Standards, Food Contact Materials,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   130-135 °C (lit.)
density   1.59 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur M01000000
  traceable to USP 1374500
SMILES string   OC(=O)\C=C/C(O)=O
InChI   1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-
InChI key   VZCYOOQTPOCHFL-UPHRSURJSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Maleic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by a spectrophotometry technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0008 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Target organs 
Respiratory system
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Acetaminophen, Caffeine, Chlorpheniramine, Ibuprofen, Naproxen, Phenylephrine, and Pseudoephedrine on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Acetaminophen, Caffeine, Chlorpheniramine, Ibuprofen, Naproxen, Phenylephrine, and Pseudoephedrine on Ascentis® Express C18
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HPLC Analysis of Antihistamines on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antihistamines on Ascentis® C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Antihistamines on Discovery® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antihistamines on Discovery® C8
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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