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PHR1279 Supelco

Sodium ascorbate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: (+)-Sodium L-ascorbate, L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt

  • CAS Number 134-03-2

  • Empirical Formula (Hill Notation) C6H7NaO6

  • Molecular Weight 198.11

  •  Beilstein/REAXYS Number 3767246

  •  EC Number 205-126-1

  •  MDL number MFCD00082340

  •  PubChem Substance ID 329823275

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, P-S, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   220 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur Y0000039
  traceable to USP 1613509
SMILES string   [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]
InChI   1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1
InChI key   PPASLZSBLFJQEF-RXSVEWSESA-M

Description

General description

Sodium ascorbate, also known as E301, is a sodium salt of ascorbic acid. It is generally used as an antioxidant in pharmaceutical formulations and food products.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards and pharmacopeia primary standards.

Application

Sodium ascorbate may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by titrimetry and liquid chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC1682 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
CI7671000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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