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PHR1284 Supelco

Chlorpropamide

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 1-(p-Chlorobenzenesulfonyl)-3-propylurea

  • CAS Number 94-20-2

  • Empirical Formula (Hill Notation) C10H13ClN2O3S

  • Molecular Weight 276.74

  •  EC Number 202-314-5

  •  MDL number MFCD00079004

  •  PubChem Substance ID 329823279

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, C-D, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur C1905000
  traceable to USP 1126009
SMILES string   CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
InChI   1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)
InChI key   RKWGIWYCVPQPMF-UHFFFAOYSA-N
Gene Information   human ... ABCC8(6833), KCNJ11(3767)

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Chlorpropamide belongs to the sulfonylurea class of drugs and is found to be clinically effective in the treatment of Diabetes mellitus (DM). Its mode of action involves the stimulation of insulin release from the β-cells of the pancreas in response to a glucose load. It helps in increasing the number of insulin receptors, thereby enhancing the effect of insulin on the liver and promotes peripheral glucose utilization.

Application

Chlorpropamide may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using capillary zone elctrophoresis technique and spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0019 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
YS6650000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

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