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Residual Solvent - Acetonitrile

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: ACN, Acetonitrile, Cyanomethane, Ethyl nitrile, Methyl cyanide

  • CAS Number 75-05-8

  • Linear Formula CH3CN

  • Molecular Weight 41.05

  •  Beilstein/REAXYS Number 741857

  •  EC Number 200-664-3

  •  MDL number MFCD00001878

  •  PubChem Substance ID 329823305

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, P-S, Pharmaceutical Secondary Standards,
grade   certified reference material
  pharmaceutical secondary standard
vapor density   1.41 (vs air)
vapor pressure   72.8 mmHg ( 20 °C)
InChI Key   WEVYAHXRMPXWCK-UHFFFAOYSA-N
autoignition temp.   973 °F
expl. lim.   16 %
refractive index   n20/D 1.344 (lit.)
bp   81-82 °C (lit.)
mp   −48 °C (lit.)
density   0.786 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   single component solution
pharmacopeia traceability   traceable to USP 1601340

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent - Acetonitrile is a CRM and Secondary Pharmaceutical Reference Standard, traceable and qualified against the corresponding Pharmacopeial standards. Sigma-Aldrich offers Fluka brand Certified Reference Materials (CRMs) for the analysis of Residual Solvents. A comprehensive Certificate of Analysis offers details of the methodology and results of the qualification.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0679 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NA 1993 / PGIII
WGK Germany 
1
Flash Point(F) 
188.6 °F
Flash Point(C) 
87 °C
Protocols & Articles

Articles

GC Analysis of Class 2 Residual Solvents on Equity®-1 after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on Equity®-1 after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Class 2 Residual Solvents on OVI-G43

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on OVI-G43
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography

GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Residual Solvents on Equity®-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Residual Solvents on Equity®-5
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Purification, Size-exclusion chromatography

GC Analysis of Residual Solvents on SPB®-1 SULFUR after SPME using 65 μm PDMS/DVB Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Residual Solvents on SPB®-1 SULFUR after SPME using 65 μm PDMS/DVB Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Purification, Solid phase microextractions

GC Analysis of Volatiles in Drywall on SPB®-HAP after Collection/Desorption using Carbotrap® 300 Tube

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles in Drywall on SPB®-HAP after Collection/Desorption using Carbotrap® 300 Tube
Keywords: Air Monitoring, Chromatography, Gas chromatography, Purification

Peer-Reviewed Papers
15

References

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