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N-Methylpyrrolidone

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 1-Methyl-2-pyrrolidinone, 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP

  • CAS Number 872-50-4

  • Empirical Formula (Hill Notation) C5H9NO

  • Molecular Weight 99.13

  •  Beilstein/REAXYS Number 106420

  •  EC Number 212-828-1

  •  MDL number MFCD00003193

  •  PubChem Substance ID 329823336

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Food & Beverage Standards, Food Contact Materials, Food and Cosmetic Component Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   3.4 (vs air)
vapor pressure   0.29 mmHg ( 20 °C)
  0.99 mmHg ( 40 °C)
form   neat
autoignition temp.   518 °F
expl. lim.   9.5 %
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.47 (lit.)
bp   202 °C (lit.)
  81-82 °C/10 mmHg (lit.)
mp   −24 °C (lit.)
density   1.028 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1437202
SMILES string   CN1CCCC1=O
InChI   1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
InChI key   SECXISVLQFMRJM-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

N-Methylpyrrolidone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB8250 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Description

Product #

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1-Methyl-2-pyrrolidinone    
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NA 1993 / PGIII
WGK Germany 
WGK 1
Flash Point(F) 
195.8 °F - Pensky-Martens closed cup
Flash Point(C) 
91 °C - Pensky-Martens closed cup
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

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1437202 Methylpyrrolidone, United States Pharmacopeia (USP) Reference Standard

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