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PHR1366 Supelco

Dibutyl Phthalate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: n-Butyl phthalate, DBP, Dibutyl phthalate, Phthalic acid dibutyl ester

  • CAS Number 84-74-2

  • Linear Formula C6H4-1,2-[CO2(CH2)3CH3]2

  • Molecular Weight 278.34

  •  Beilstein/REAXYS Number 1914064

  •  EC Number 201-557-4

  •  MDL number MFCD00009441

  •  PubChem Substance ID 329823345

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, C-D, Chinese Food Contact Materials Regulation GB 9685 2016, Food & Beverage Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   9.6 (vs air)
vapor pressure   1 mmHg ( 147 °C)
autoignition temp.   756 °F
expl. lim.   0.47 %, 236 °F
packaging   pkg of 1 g
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.492 (lit.)
bp   340 °C (lit.)
mp   −35 °C (lit.)
density   1.043 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur D1010000
  traceable to USP 1187080
SMILES string   CCCCOC(=O)c1ccccc1C(=O)OCCCC
InChI   1S/C16H22O4/c1-3-5-11-19-15(17)13-9-7-8-10-14(13)16(18)20-12-6-4-2/h7-10H,3-6,11-12H2,1-2H3
InChI key   DOIRQSBPFJWKBE-UHFFFAOYSA-N

Description

General description

Dibutyl Phthalate is a diester of phthalate, commonly synthesized by the condensation of the carboxy groups of phthalic acid with two molecules of 1-butanol. It is used as a plasticizer and film coating agent in solid pharmaceutical dosage forms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Dibutyl Phthalate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and dietary supplements by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Plasticizer

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA1470 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
339.8 °F
Flash Point(C) 
171 °C
Protocols & Articles

Articles

Qualification of Sunscreens Using Certified Reference Materials

Absorbing the sun’s rays helps the body create an important nutrient, Vitamin D, for immune system function and proper bone density. Exposing oneself to sunlight can have positive effects - setting t...
Keywords: Absorption, Cancer, Pharmaceutical, Vitamins

Peer-Reviewed Papers
15

References

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