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PHR1372 Supelco

Methanol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Methanol, Methyl alcohol

  • CAS Number 67-56-1

  • Linear Formula CH3OH

  • Molecular Weight 32.04

  •  Beilstein/REAXYS Number 1098229

  •  EC Number 200-659-6

  •  MDL number MFCD00004595

  •  PubChem Substance ID 329823350

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Chinese Food Contact Materials Regulation GB 9685 2016, Food & Beverage Standards, Food Contact Materials,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   1.11 (vs air)
vapor pressure   410 mmHg ( 50 °C)
  97.68 mmHg ( 20 °C)
form   neat
autoignition temp.   725 °F
expl. lim.   36 %
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.329 (lit.)
bp   64.7 °C (lit.)
mp   −98 °C (lit.)
density   0.791 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1424109
SMILES string   CO
InChI   1S/CH4O/c1-2/h2H,1H3
InChI key   OKKJLVBELUTLKV-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Methanol is a widely used polar organic solvent in chemistry, biochemistry, and molecular biology. It is a common solvent in HPLC and mass spectrometry (MS) of small molecules and of biomolecules such as oligonucleotides and proteins. Methanol is also utilized in high performance capillary electrophoresis. Industrial applications of methanol include the manufacture of formaldehyde and methyl esters of organic and inorganic acids. Methanol is used as a solvent and solvent adjuvant for polymers, and as a softening agent for pyroxylin plastics.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7353 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Eyes
RIDADR 
UN1230 - class 3 - PG 2 - Methanol
WGK Germany 
WGK 2
Flash Point(F) 
49.5 °F - closed cup
Flash Point(C) 
9.7 °C - closed cup
Protocols & Articles

Articles

ASTM D5501: GC Analysis of Ethanol on Petrocol® DH 150

From our library of Articles, Sigma-Aldrich presents ASTM D5501: GC Analysis of Ethanol on Petrocol® DH 150
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Alcoholic Spirit on Equity®-1 °Coupled to SUPELCOWAX 10 (Column Set 2)

From our library of Articles, Sigma-Aldrich presents GC Analysis of Alcoholic Spirit on Equity®-1 °Coupled to SUPELCOWAX 10 (Column Set 2)
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Blood Alcohols in Human Plasma on SUPELCOWAX® 10 after SPME using 60 μm Carbowax® Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Blood Alcohols in Human Plasma on SUPELCOWAX® 10 after SPME using 60 μm Carbowax® Fiber
Keywords: Chromatography, Clinical, Flame ionization detector, Forensic, Gas chromatography, Pharmaceutical, Purification, Solid phase microextractions

GC Analysis of Blood Alcohols on SUPELCOWAX® 10

From our library of Articles, Sigma-Aldrich presents GC Analysis of Blood Alcohols on SUPELCOWAX® 10
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Blood Alcohols on a Packed Column (5% Carbowax® 20M on 60/80 °Carbopack™ B)

From our library of Articles, Sigma-Aldrich presents GC Analysis of Blood Alcohols on a Packed Column (5% Carbowax® 20M on 60/80 °Carbopack™ B)
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Class 2 Residual Solvents on Equity®-1 after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on Equity®-1 after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Class 2 Residual Solvents on OVI-G43

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on OVI-G43
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography

GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Fermentation Compounds on a Packed Column (6.6% Carbowax® 20M on 80/120 °Carbopack™ B AW)

From our library of Articles, Sigma-Aldrich presents GC Analysis of Fermentation Compounds on a Packed Column (6.6% Carbowax® 20M on 80/120 °Carbopack™ B AW)
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Impurities in MTBE on Petrocol® DH Octyl

From our library of Articles, Sigma-Aldrich presents GC Analysis of Impurities in MTBE on Petrocol® DH Octyl
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Impurities in MTBE on Petrocol® DH

From our library of Articles, Sigma-Aldrich presents GC Analysis of Impurities in MTBE on Petrocol® DH
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Industrial Solvents on Equity®-1701

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1701
Keywords: Chromatography, Flame ionization detector, Gas chromatography

GC Analysis of Industrial Solvents on Equity®-1

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Industrial Solvents on SUPELCOWAX 10

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on SUPELCOWAX 10
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Isooctyl Alcohols on Nukol™

From our library of Articles, Sigma-Aldrich presents GC Analysis of Isooctyl Alcohols on Nukol™
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Residual Solvents on SPB®-624 after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Residual Solvents on SPB®-624 after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Purification, Sample preparations, Solid phase microextractions

GC Analysis of Scotch Whiskey on a Packed Column (5% Carbowax® 20M on 80/120 °Carbopack B)

From our library of Articles, Sigma-Aldrich presents GC Analysis of Scotch Whiskey on a Packed Column (5% Carbowax® 20M on 80/120 °Carbopack B)
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Scotch Whiskey on a Packed Column (6.6% Carbowax® 20M on 80/120 °Carbopack B AW)

From our library of Articles, Sigma-Aldrich presents GC Analysis of Scotch Whiskey on a Packed Column (6.6% Carbowax® 20M on 80/120 °Carbopack B AW)
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Solvents in Water on SPB®-1 SULFUR after SPME using 75 μm Carboxen/PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Solvents in Water on SPB®-1 SULFUR after SPME using 75 μm Carboxen/PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Solid phase microextractions, Solvents

GC Analysis of Solvents on a Packed Column (3% SP-1500 on Carbopack™ B)

From our library of Articles, Sigma-Aldrich presents GC Analysis of Solvents on a Packed Column (3% SP-1500 on Carbopack™ B)
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Volatiles in Water on Equity®-1 after SPME using 30 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles in Water on Equity®-1 after SPME using 30 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of a 56-Component Industrial Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column

From our library of Articles, Sigma-Aldrich presents GC Analysis of a 56-Component Industrial Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column
Keywords: Chromatography, Flame ionization detector, Gas chromatography

HPLC Analysis of Allegra® on Discovery® Cyano

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Allegra® on Discovery® Cyano
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

US EPA Method 0030: GC Analysis of Volatiles on SPB®-624 after Collection/Desorption using VOST 100 Tube

From our library of Articles, Sigma-Aldrich presents US EPA Method 0030: GC Analysis of Volatiles on SPB®-624 after Collection/Desorption using VOST 100 Tube
Keywords: Air Monitoring, Chromatography, Flame ionization detector, Gas chromatography, Purification

Peer-Reviewed Papers
15

References

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