EMAIL THIS PAGE TO A FRIEND
PHR1385 Supelco

Ketoconazole

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: (±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine, Ketoconazole

Purchase

Properties

Related Categories Analytical Standards, Analytical/Chromatography, K-O, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   XMAYWYJOQHXEEK-OZXSUGGESA-N
form   neat
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur K0600000
  traceable to USP 1356508

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ketoconazole is an imidazole antifungal agent administered through topical or oral means. It is used for the treatment of chronic mucocutaneous candidiasis, fungal infections of the gastro-intestinal tract, dermatophyte infections, systemic infections, and fungal infections in immuno-compromised patients.

Application

Ketoconazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

CYP3A4 inhibitor

Biochem/physiol Actions

Antifungal agent

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3465 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
3

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of CYP3A Inhibitors on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of CYP3A Inhibitors on Ascentis® Express RP-Amide
Keywords: Chromatography, Clinical, High performance liquid chromatography

HPLC Analysis of Ketoconazole Enantiomers on Astec® CYCLOBOND® I 2000 HP-RSP

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ketoconazole Enantiomers on Astec® CYCLOBOND® I 2000 HP-RSP
Keywords: Antibiotics, Antifungals, Antimicrobials, Chromatography, High performance liquid chromatography, Pharmaceutical

LC/MS Analysis of Antifungals on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antifungals on Ascentis® Express Biphenyl
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical

LC/MS Analysis of Antifungals on Ascentis® Express Phenyl-Hexyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antifungals on Ascentis® Express Phenyl-Hexyl
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical

UHPLC Analysis of Antifungals on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Antifungals on Ascentis® Express C18
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

UHPLC Analysis of Antifungals on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Antifungals on Titan™ C18
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?