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PHR1393 Supelco

Ampicillin Trihydrate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: D-(−)-α-Aminobenzylpenicillin, Ampicillin trihydrate

  • CAS Number 7177-48-2

  • Empirical Formula (Hill Notation) C16H19N3O4S · 3H2O

  • Molecular Weight 403.45

  •  Beilstein/REAXYS Number 5399534

  •  EC Number 200-709-7

  •  MDL number MFCD00072036

  •  PubChem Substance ID 329823367

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Properties

Related Categories A-C, Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography,
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   RXDALBZNGVATNY-CWLIKTDRSA-N
form   neat
mp   198-200 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 785
  traceable to PhEur A1000000
  traceable to USP 1033000/1033407

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Ampicillin trihydrate may be used as an analytical reference standard for the determination of ampicillin in plasma samples and pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli . Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA1900 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
XH8425000

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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