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Promethazine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride, Promethazine hydrochloride

  • CAS Number 58-33-3

  • Empirical Formula (Hill Notation) C17H20N2S · HCl

  • Molecular Weight 320.88

  •  Beilstein/REAXYS Number 4166397

  •  EC Number 200-375-2

  •  MDL number MFCD00012652

  •  PubChem Substance ID 329823397

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, P-S, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   XXPDBLUZJRXNNZ-UHFFFAOYSA-N
packaging   pkg of 1 g
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 421
  traceable to PhEur P3400000
  traceable to USP 1570009

Description

General description

Promethazine hydrochloride belongs to the group of phenothiazine derivatives. It is commonly used as an antihistaminic for most prominently enhancing the anesthetic, sedative and analgesic effect of other drugs. It also shows antipyretic and antiemetic properties, when used in combination with paracetamol. It is also used to provide symptomatic relief of hypersensitivity reactions.

Application

Promethazine hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectroanalytical technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3015 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
SO8225000

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of Promethazine Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Promethazine Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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